Immune receptor toll-like receptor 4 contributes to stress-induced affective responses in a sex-specific manner
Stress activates innate immune Toll-like receptors (TLRs) and enhances susceptibility to depression, a condition that is more prevalent in females.The TLR4 receptor type is involved in inflammatory responses and its expression levels associate with depressive symptoms and their successful treatment.Yet, little preclinical research has examined the